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How many times have you entered a supermarket for enfamil vs similac, went to the baby formula aisle, and wished that you could have your baby sample taste all formulas before investing in one? But, do you know which is the best baby formula for your little one?
Finding the right baby formula for your infant is a difficult task since all babies have varied requirements. While some babies do better on regular formula, some need special attention with spit-up specific or sensitive stomach specific formulas. Even if you luckily find a brand that works well, that’s still only half the battle because most brands further have different types of formulas under one brand name.
The most popular baby formula brands: Enfamil and Similac also have at least 5 different types of formulas each. We totally understand what a pain finding the right baby formula could be and on that note, we have taken the responsibility of finding you the best baby formula for your baby.
In this blog ahead, on the basis of our exhaustive research, we have compared 6 similar versions of both brands, Enfamil and Similac. We attempt to offer you all the information you’d need to make an informed decision for your baby.
Enfamil vs Similac
1. Enfamil Gentlease Infant Formula vs Similac Sensitive Infant Formula; Best Baby Formula


Point of comparison/ Formula name | Enfamil Gentlease Infant Formula | Similac Sensitive Non-GMO Infant Formula |
Purpose | Both of these formulas are made specifically for babies with a sensitive stomach and those who show some vulnerability to gas and fussiness. While they are different on some parameters, the goal of both these formulas remains to “reduce gas, crying, and fussiness.” | |
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Differences between formulas | Uses partially hydrolyzed nonfat milk and whey protein concentrate solids from soy that aid a baby’s sensitive stomach to seamlessly digest cow milk. |
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Our verdict: Enfamil Gentlease stands as a clear winner here owing to the fact that their ingredients are much more gentle for a baby who suffers from gas. They also do not use any added sugars and do not contain the milk protein isolate which, ironically, can cause indigestion in a baby. However, if you already have tried Gentlease and your baby does not seem to like it, Similac’s Sensitive formula could be the next best alternative. |
2. Enfamil A.R. Infant Formula vs Similac Spit-Up Infant Formula; Best Baby Formula


Point of comparison/ Formula name | Enfamil A.R Has a thick formula equipped with prebiotics that enhances digestion. | Similac Spit-Up Similac does not go into detail about their formula, and all we know is that it is meant to reduce spit-up. |
Purpose | Both of these formulas specifically cater to babies who struggle with a spit-up problem. While 5 spit-ups per day are considered normal, some babies tend to spit up more than that due to their generally sensitive stomachs. | |
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Differences between formulas |
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Our verdict: None of these two formulas are perfectly ideal. However, because Enfamil contains less sugar and more prebiotics as against Similac, they are a winner again. |
3. Enfamil Nutramigen with Enflora LGG Infant Formula vs Similac Expert Care Alimentum Hypoallergenic Infant Formula; Best Baby Formula


Point of comparison/ Formula name | Enfamil Nutramigen | Similac Alimentum
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Our verdict: Enfamil’s Nutramigen wins again since it is not only easier to digest but also helps babies tolerate milk better as they grow up. Another winning point is the fact that they do not add sugars after cornstarch as Similac does. |
4. Enfamil Infant Milk-based Baby Formula vs Similac Advance Complete Nutrition Infant Formula; Best Baby Formula


Point of comparison/ Formula name | Enfamil Infant Milk-based | Similac Advance Complete Nutrition
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Purpose | Both of these formulas intend to provide the basic nourishment required by a baby in their initial years of life. Both of these products are basic baby formula models. | |
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Differences between formulas |
Palm Olein oil is a fatty acid similar to breast milk and can be difficult on sensitive baby tummies. |
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Our verdict: Similac Advance Formula is a clear winner over Enfamil’s Infant Formula not only because it contains Lutein but also for the lack of potentially problematic Palm Olein Oil. |
5. Enfamil NeuroPro vs Similac 2′ -FL HMO Pro Advance; Best Baby Formula


Point of comparison/ Formula name | Enfamil NutramigeNeuroPro | Similac 2′ -FL HMO
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Purpose | Both formulas intend to mimic breast milk with their formula by attempting to supply as many nutrients as available in breastmilk, albeit in powder milk. | |
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Our verdict: Both of these formulas are excellent in what they do. While Enfamil NutramigeNeuroPro effectively helps support the development of the brain, given the ingredients; Similac 2′ -FL HMO helps boost the immunity. You should pick between these formulas on the basis of the requirements of the baby. For example, if the baby is weaker than other babies of the age, try Similac 2′ -FL HMO Pro Advance. If you do not have any problems with the baby’s immunity and if your baby is as healthy as they should ideally be, Enfamil’s Neuro-Pro could be a wise choice. |
6. Enfamil ProSobee vs. Similac Soy Isomil; Best Baby Formula


Point of comparison/ Formula name | Enfamil ProSobee | Similac Soy Isomil |
Purpose | Both Enfamil and Similac offer a complete milk-free formula for those babies who cannot digest cow’s milk proteins. Soy-based formulas are a natural and gentle alternative for lactose intolerant babies. | |
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Our verdict: Only since Enfamil’s ProSobee recipe uses fewer sugars, it is a better option in our opinion. |
7. Enfamil Enfagrow Premium vs. Similac Go And Grow; Best Baby Formula


Point of comparison/ Formula name | Enfamil Enfagrow Premium | Similac Go And Grow
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Purpose | Both Enfamil Enfagrow Premium and Similac Go & Grow, give a good nutritious foundation for your toddler’s development. | |
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Differences between formulas |
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Our verdict: Since Enfamil has twice as much DHA as Similac and has 30% less sugar, Enfamil is a better choice. |
Enfamil vs Similac FAQs :
1. How do I know when a baby formula does not suit my baby ?
2. Can I add my one ingredients to a store-bought baby formula ?
3. Can I DIY baby formula ?
4. Can babies drink two different formulas ?
5. What is the best baby formula offered by Enfamil and Similac ?
Point of comparison/ Formula name | Enfamil NeuroPro Infant Formula | Similac Pro-Advance Non-GMO Infant Formula |
Contents |
6. Is it safe to breastfeed and use formula too ?
7. Is it ok to feed babies two different formulas ?
8. Is it true that babies who drink formula tend to sleep much better ?
9. Does not wearing a bra increase milk supply ?
Reviewed By-

Brandi Nicole, Lactation Consultant
Brandi Nicole is a pediatric nurse, a postpartum doula, and an international board-certified lactation consultant. She is a proud member of the International Lactation Consultant Association, the United States Lactation Consultant Association, and the Bay Area Lactation Associates.